脂蛋白(a)抑制脂多糖诱导人单核细胞产生肿瘤坏死因子α 。
Lipoprotein(a) inhibits lipopolysaccharide-induced tumor necrosis factor alpha production by human mononuclear cells.
作者信息
Netea M G, de Bont N, Demacker P N, Kullberg B J, Jacobs L E, Verver-Jansen T J, Stalenhoef A F, Van der Meer J W
机构信息
Department of Medicine, University Hospital Nijmegen, The Netherlands.
出版信息
Infect Immun. 1998 May;66(5):2365-7. doi: 10.1128/IAI.66.5.2365-2367.1998.
Abstract
Lipoproteins can bind lipopolysaccharide (LPS) and decrease LPS-stimulated cytokine production. Lipoprotein(a) [Lp(a)] was as potent as low-density lipoproteins (LDL) in inhibiting LPS-stimulated tumor necrosis factor synthesis by human mononuclear cells. The kinetics of LPS inhibition by Lp(a) was similar to that of LDL. This suggests that circulating Lp(a) may be an important factor determining the amplitude of the response to LPS in humans.
摘要
脂蛋白可以结合脂多糖（LPS）并减少LPS刺激的细胞因子产生。脂蛋白(a) [Lp(a)]在抑制LPS刺激人单核细胞合成肿瘤坏死因子方面与低密度脂蛋白（LDL）同样有效。Lp(a)对LPS的抑制动力学与LDL相似。这表明循环中的Lp(a)可能是决定人类对LPS反应幅度的一个重要因素。
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