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Survey and molecular genetics of SHV beta-lactamases in Enterobacteriaceae in Switzerland: two novel enzymes, SHV-11 and SHV-12.瑞士肠杆菌科细菌中SHVβ-内酰胺酶的调查与分子遗传学研究：两种新型酶，SHV-11和SHV-12
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Comparative characterization of the cephamycinase blaCMY-1 gene and its relationship with other beta-lactamase genes.头孢菌素酶blaCMY-1基因的比较特征及其与其他β-内酰胺酶基因的关系。
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TEM- and SHV-derived extended-spectrum beta-lactamases: relationship between selection, structure and function.源自 TEM 和 SHV 的超广谱β-内酰胺酶：选择、结构与功能之间的关系
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Extended broad spectrum beta-lactamase in Klebsiella pneumoniae including resistance to cephamycins.肺炎克雷伯菌中的超广谱β-内酰胺酶，包括对头孢霉素的耐药性。
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Nucleotide sequence of the gene encoding the SHV-2 beta-lactamase (blaSHV-2) of Klebsiella ozaenae.臭鼻克雷伯菌SHV-2β-内酰胺酶（blaSHV-2）编码基因的核苷酸序列。
Nucleic Acids Res. 1990 Aug 25;18(16):4916. doi: 10.1093/nar/18.16.4916.
8
Nucleotide sequence and phylogeny of SHV-2 beta-lactamase.SHV-2β-内酰胺酶的核苷酸序列与系统发育
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Cloning of SHV-2, OHIO-1, and OXA-6 beta-lactamases and cloning and sequencing of SHV-1 beta-lactamase.SHV-2、OHIO-1和OXA-6β-内酰胺酶的克隆以及SHV-1β-内酰胺酶的克隆与测序。
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10
Nucleotide sequence of SHV-2 beta-lactamase gene.SHV-2β-内酰胺酶基因的核苷酸序列。
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产超广谱β-内酰胺酶肺炎克雷伯菌菌株的调查：韩国SHV-12和SHV-2a的流行情况

Survey of Klebsiella pneumoniae strains producing extended-spectrum beta-lactamases: prevalence of SHV-12 and SHV-2a in Korea.

作者信息

Kim J, Kwon Y, Pai H, Kim J W, Cho D T

机构信息

Department of Microbiology, College of Medicine, Dankook University, Chonan, Chungnam, Korea.

出版信息

J Clin Microbiol. 1998 May;36(5):1446-9. doi: 10.1128/JCM.36.5.1446-1449.1998.

DOI:10.1128/JCM.36.5.1446-1449.1998
PMID:9574728
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC104851/
Abstract

Fifty-three clinical isolates of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae collected from three hospitals in Korea were investigated for phenotypical and genotypical characterizations. Among these, 39 strains (74%) were shown by isoelectric focusing to carry SHV-type beta-lactamases: 27 strains showed the pI 8.2 beta-lactamase, and another 12 strains showed the pI 7.6 beta-lactamase. The SHV gene of each of these strains was amplified by PCR, followed by nucleotide sequencing analysis. The gene of the pI 8.2 beta-lactamase was found to be identical to the sequences encoding SHV-12, and the gene of the pI 7.6 beta-lactamase was identical to the sequences encoding SHV-2a. A total of eight cefoxitin-resistant strains were found to have the plasmid-mediated AmpC-type beta-lactamase, with a pI of 8.0, and this was confirmed to be CMY-1 beta-lactamase by PCR and hybridization analysis. Noteworthy in this study is the fact that SHV-12 and SHV-2a have been the most commonly identified SHV-type ESBLs in Korea.

摘要

对从韩国三所医院收集的53株产超广谱β-内酰胺酶（ESBL）的肺炎克雷伯菌临床分离株进行了表型和基因型特征研究。其中，39株（74%）经等电聚焦显示携带SHV型β-内酰胺酶：27株显示pI 8.2β-内酰胺酶，另外12株显示pI 7.6β-内酰胺酶。对这些菌株的每一株SHV基因进行PCR扩增，随后进行核苷酸序列分析。发现pI 8.2β-内酰胺酶的基因与编码SHV-12的序列相同，pI 7.6β-内酰胺酶的基因与编码SHV-2a的序列相同。共发现8株头孢西丁耐药菌株具有质粒介导的AmpC型β-内酰胺酶，pI为8.0，经PCR和杂交分析证实为CMY-1β-内酰胺酶。本研究中值得注意的是，SHV-12和SHV-2a是韩国最常见的SHV型ESBLs。