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产超广谱β-内酰胺酶肺炎克雷伯菌菌株的调查：韩国SHV-12和SHV-2a的流行情况

Survey of Klebsiella pneumoniae strains producing extended-spectrum beta-lactamases: prevalence of SHV-12 and SHV-2a in Korea.

作者信息

Kim J, Kwon Y, Pai H, Kim J W, Cho D T

机构信息

Department of Microbiology, College of Medicine, Dankook University, Chonan, Chungnam, Korea.

出版信息

J Clin Microbiol. 1998 May;36(5):1446-9. doi: 10.1128/JCM.36.5.1446-1449.1998.

DOI:10.1128/JCM.36.5.1446-1449.1998
PMID:9574728
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC104851/
Abstract

Fifty-three clinical isolates of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae collected from three hospitals in Korea were investigated for phenotypical and genotypical characterizations. Among these, 39 strains (74%) were shown by isoelectric focusing to carry SHV-type beta-lactamases: 27 strains showed the pI 8.2 beta-lactamase, and another 12 strains showed the pI 7.6 beta-lactamase. The SHV gene of each of these strains was amplified by PCR, followed by nucleotide sequencing analysis. The gene of the pI 8.2 beta-lactamase was found to be identical to the sequences encoding SHV-12, and the gene of the pI 7.6 beta-lactamase was identical to the sequences encoding SHV-2a. A total of eight cefoxitin-resistant strains were found to have the plasmid-mediated AmpC-type beta-lactamase, with a pI of 8.0, and this was confirmed to be CMY-1 beta-lactamase by PCR and hybridization analysis. Noteworthy in this study is the fact that SHV-12 and SHV-2a have been the most commonly identified SHV-type ESBLs in Korea.

摘要

对从韩国三所医院收集的53株产超广谱β-内酰胺酶（ESBL）的肺炎克雷伯菌临床分离株进行了表型和基因型特征研究。其中，39株（74%）经等电聚焦显示携带SHV型β-内酰胺酶：27株显示pI 8.2β-内酰胺酶，另外12株显示pI 7.6β-内酰胺酶。对这些菌株的每一株SHV基因进行PCR扩增，随后进行核苷酸序列分析。发现pI 8.2β-内酰胺酶的基因与编码SHV-12的序列相同，pI 7.6β-内酰胺酶的基因与编码SHV-2a的序列相同。共发现8株头孢西丁耐药菌株具有质粒介导的AmpC型β-内酰胺酶，pI为8.0，经PCR和杂交分析证实为CMY-1β-内酰胺酶。本研究中值得注意的是，SHV-12和SHV-2a是韩国最常见的SHV型ESBLs。

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