SHV-2β-内酰胺酶基因的核苷酸序列。
Nucleotide sequence of SHV-2 beta-lactamase gene.
作者信息
Garbarg-Chenon A, Godard V, Labia R, Nicolas J C
机构信息
Laboratoire de Microbiologie, Hopital Trousseau, Paris, France.
出版信息
Antimicrob Agents Chemother. 1990 Jul;34(7):1444-6. doi: 10.1128/AAC.34.7.1444.
Abstract
The nucleotide sequence of plasmid-mediated beta-lactamase SHV-2 from Salmonella typhimurium (SHV-2pHT1) was determined. The gene was very similar to chromosomally encoded beta-lactamase LEN-1 of Klebsiella pneumoniae. Compared with the sequence of the Escherichia coli SHV-2 enzyme (SHV-2E.coli) obtained by protein sequencing, the deduced amino acid sequence of SHV-2pHT1 differed by three amino acid substitutions.
摘要
测定了鼠伤寒沙门氏菌质粒介导的β-内酰胺酶SHV-2（SHV-2pHT1）的核苷酸序列。该基因与肺炎克雷伯菌染色体编码的β-内酰胺酶LEN-1非常相似。与通过蛋白质测序获得的大肠杆菌SHV-2酶（SHV-2E.coli）的序列相比，SHV-2pHT1的推导氨基酸序列有三个氨基酸取代的差异。
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