Taylor J A, Williams T D, Seals D R, Davy K P
Hebrew Rehabilitation Center for Aged, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Am J Physiol. 1998 Apr;274(4):H1194-201. doi: 10.1152/ajpheart.1998.274.4.H1194.
Low-frequency arterial pressure oscillations (Mayer waves) have been proposed as an index of vascular sympathetic outflow. However, cross-sectional differences in these pressure oscillations may not reflect different levels of sympathetic nervous outflow in humans. Three groups of healthy subjects with characteristically different sympathetic nervous outflow were studied: young females (n = 10, 18-28 yr), young males (n = 11, 18-29 yr), and older males (n = 13, 60-72 yr). Average R-R interval, arterial pressures, and systolic pressure variability at the Mayer wave frequency (0.05-0.15 Hz) did not differ among the three groups. Diastolic pressure Mayer wave variability was similar in young females vs. young males (39 +/- 10 vs. 34 +/- 5 mmHg2) and lower in older males vs. young males (14 +/- 2 mmHg2; P < 0.05). In contrast, muscle sympathetic activity was lowest in young females (892 +/- 249 total activity/min) and highest in older males (3,616 +/- 528 total activity/min; both P < 0.05 vs. young males: 2,505 +/- 285 total activity/min). Across the three groups, arterial pressure Mayer wave variability did not correlate with any index of sympathetic activity. Our results demonstrate that arterial pressure Mayer wave amplitude is not a surrogate measure of vascular sympathetic outflow.
低频动脉压振荡（迈尔波）已被提议作为血管交感神经输出的一个指标。然而，这些压力振荡的横断面差异可能无法反映人类交感神经输出的不同水平。研究了三组具有不同特征性交感神经输出的健康受试者：年轻女性（n = 10，18 - 28岁）、年轻男性（n = 11，18 - 29岁）和老年男性（n = 13，60 - 72岁）。三组之间的平均R - R间期、动脉压以及迈尔波频率（0.05 - 0.15 Hz）下的收缩压变异性并无差异。年轻女性与年轻男性的舒张压迈尔波变异性相似（分别为39±10与34±5 mmHg²），而老年男性与年轻男性相比则较低（14±2 mmHg²；P < 0.05）。相反，肌肉交感神经活动在年轻女性中最低（892±249次总活动/分钟），在老年男性中最高（3616±528次总活动/分钟；与年轻男性相比，两者P < 0.05：2505±285次总活动/分钟）。在三组中，动脉压迈尔波变异性与交感神经活动的任何指标均无相关性。我们的结果表明，动脉压迈尔波振幅并非血管交感神经输出的替代指标。
