Penagini R, Mangano M, Bianchi P A
Cattedra di Gastroenterologia, University of Milan-IRCCS Ospedale Maggiore, Italy.
Gut. 1998 Mar;42(3):330-3. doi: 10.1136/gut.42.3.330.
Although fatty foods are commonly considered detrimental in patients with reflux disease, no objective data exist that substantiate this belief.
To investigate the effect of fat on gastro-oesophageal reflux and lower oesophageal sphincter (LOS) motor activity.
Thirteen healthy subjects and 14 patients with reflux disease.
Oesophageal pH, LOS, and oesophageal pressures were recorded for 180 minutes after a high fat (52% fat) and a balanced (24% fat) meal (both 3.18 MJ) on two different occasions. Eight controls and seven patients were studied in the recumbent position and the others in the sitting position.
The percentage of time at pH less than 4 and the rate of reflux episodes were higher (p < 0.01) in the patients than in the healthy subjects (mean 14.1% versus 1.7% and 4.4/h versus 0.8/h respectively), as was the percentage of transient LOS relaxations associated with reflux (62% versus 32%, p < 0.01). The high fat meal did not increase the rate of reflux episodes nor exposure to oesophageal acid in either group regardless of body posture. The rate of transient LOS relaxations, their association with reflux, and basal LOS pressure were also unaffected.
Increasing fat intake does not affect gastro-oesophageal reflux or oesophagogastric competence for at least three hours after a meal.
尽管脂肪类食物通常被认为对反流性疾病患者有害，但尚无客观数据证实这一观点。
研究脂肪对胃食管反流及食管下括约肌（LOS）运动活性的影响。
13名健康受试者和14名反流性疾病患者。
在两种不同情况下，分别于高脂餐（脂肪含量52%）和均衡餐（脂肪含量24%）（均为3.18兆焦耳）后180分钟记录食管pH值、LOS及食管压力。8名对照组受试者和7名患者取卧位进行研究，其余受试者取坐位。
患者pH值小于4的时间百分比及反流发作率高于健康受试者（p < 0.01）（分别为平均14.1%对1.7%以及4.4次/小时对0.8次/小时），与反流相关的LOS短暂松弛百分比也是如此（62%对32%，p < 0.01）。无论身体姿势如何，高脂餐均未增加两组的反流发作率或食管酸暴露。LOS短暂松弛率、其与反流的关联以及LOS基础压力也未受影响。
餐后至少三小时内，增加脂肪摄入量不会影响胃食管反流或食管胃的功能。
