小鼠基因组的高分辨率微卫星图谱。

A high-resolution microsatellite map of the mouse genome.

作者信息

Rhodes M, Straw R, Fernando S, Evans A, Lacey T, Dearlove A, Greystrong J, Walker J, Watson P, Weston P, Kelly M, Taylor D, Gibson K, Mundy C, Bourgade F, Poirier C, Simon D, Brunialti A L, Montagutelli X, Gu'enet J L, Haynes A, Brown S D

机构信息

United Kingdom Human Genome Mapping Project (HGMP) Resource Centre, Hinxton CB10 1RQ, UK.

出版信息

Genome Res. 1998 May;8(5):531-42. doi: 10.1101/gr.8.5.531.

DOI:10.1101/gr.8.5.531

PMID:9582196

Abstract

The European Collaborative Interspecific Backcross (EUCIB) resource was constructed for the purposes of high-resolution genetic mapping of the mouse genome (). The large Mus spretus/C57BL/6 backcross of 982 progeny has a genetic resolution of 0.3 cM at the 95% confidence level ( approximately 500 kb in the mouse genome). We have used the EUCIB mapping resource to develop a genome-wide high-resolution genetic map incorporating 3368 microsatellites. The microsatellites are distributed among 2302 genetically separated bins with 1.46 markers per bin on average. Average bin separation is 0.61 cM. This high-resolution genetic map will aid the construction of a robust physical map of the mouse genome.

摘要

欧洲种间回交协作组（EUCIB）资源库是为小鼠基因组的高分辨率遗传图谱构建而建立的（）。982个后代的大型小家鼠/ C57BL / 6回交群体在95％置信水平下的遗传分辨率为0.3 cM（在小鼠基因组中约为500 kb）。我们利用EUCIB图谱资源开发了一个全基因组高分辨率遗传图谱，其中包含3368个微卫星。这些微卫星分布在2302个遗传分离的区间中，每个区间平均有1.46个标记。区间平均间距为0.61 cM。这个高分辨率遗传图谱将有助于构建一个可靠的小鼠基因组物理图谱。