来自光叶番荔枝的生物活性贝壳杉烷二萜类化合物。
Bioactive kaurane diterpenoids from Annona glabra.
作者信息
Chang F R, Yang P Y, Lin J Y, Lee K H, Wu Y C
机构信息
Graduate Institute of Natural Products, Kaosiung Medical College, Taiwan, Republic of China.
出版信息
J Nat Prod. 1998 Apr;61(4):437-9. doi: 10.1021/np970497z.
Phytochemical analysis of the fruits of Annona glabra yielded two new kaurane diterpenoids, annoglabasin A (methyl-16 beta-acetoxy-19-al-ent-kauran-17-oate)(1) and annoglabasin B (16 alpha-hydro-19-acetoxy-ent-kauran-17-oic acid)(2), along with 11 known kaurane derivatives (3-13). The structures of the new compounds were established by spectral and chemical evidence. Among these, methyl-16 alpha-hydro-19-al-ent-kauran-17-oate (11) exhibited mild activity against HIV replication in H9 lymphocyte cells, and 16 alpha-17-dihydroxy-ent-kauran-19-oic acid (4) showed significant inhibition of HIV-reverse transcriptase.
对光滑番荔枝果实进行的植物化学分析得到了两种新的贝壳杉烷二萜，番荔枝皂苷A（16β-乙酰氧基-19-醛基-对映-贝壳杉烷-17-酸甲酯）（1）和番荔枝皂苷B（16α-氢-19-乙酰氧基-对映-贝壳杉烷-17-酸）（2），以及11种已知的贝壳杉烷衍生物（3 - 13）。通过光谱和化学证据确定了新化合物的结构。其中，16α-氢-19-醛基-对映-贝壳杉烷-17-酸甲酯（11）在H9淋巴细胞中对HIV复制表现出温和的活性，16α-17-二羟基-对映-贝壳杉烷-19-酸（4）对HIV逆转录酶表现出显著的抑制作用。
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