Schmid J, Wallkamm B, Hämmerle C H, Gogolewski S, Lang N P
Department of Periodontology and Fixed Prosthodontics, University of Berne, Switzerland.
Clin Oral Implants Res. 1997 Jun;8(3):244-8. doi: 10.1034/j.1600-0501.1997.080311.x.
A dome-shaped bioresorbable membrane was fixed to the wounded rabbit calvaria and filled with a bioresorbable fibre conglomerate. After 4 weeks, the histologic preparation revealed an intimate spatial and temporal correlation between newly formed blood vessels and de novo extraskeletal bone formation. These observations emphasize the significance of angiogenesis in guided bone generation.