Lundgren A K, Lundgren D, Sennerby L, Taylor A, Gottlow J, Nyman S
Department of Biomaterials/Handicap Research, Institute for Surgical Sciences, Göteborg University, Sweden.
Clin Oral Implants Res. 1997 Apr;8(2):90-5. doi: 10.1034/j.1600-0501.1997.080203.x.
The aim of this experimental investigation was to compare the effect of using autologous particulate bone grafts with and without a bioresorbable barrier covering for augmentation of the rabbit skull bone. For this purpose, bilateral, circular, 8 mm wide and 1 mm deep skull bone defects were prepared and overfilled with particulate bone grafts. The grafts placed in the test sites were covered with a bioresorbable barrier (Guidor Matrix Barrier). The grafts placed in the control sites were covered only by the repositioned, cutaneous flap. 12 weeks later, the animals were sacrificed, the experimental sites were defleshed and the height and volume of the augmented bone in the test and control sites were measured clinically. Histologically, morphometrical measurements of the bone tissue were performed in decalcified vertical cross-sections of the experimental sites. Statistically significant differences were found in favour of the coverage of the bone graft particles with the barrier, both with respect to the height and the volume of the augmented bone.
本实验研究的目的是比较使用有和没有生物可吸收屏障覆盖的自体颗粒骨移植对兔颅骨增容的效果。为此，制备了双侧圆形、宽8毫米、深1毫米的颅骨缺损，并在其上过度填充颗粒骨移植材料。放置在测试部位的移植材料用生物可吸收屏障（Guidor基质屏障）覆盖。放置在对照部位的移植材料仅用重新定位的皮瓣覆盖。12周后，处死动物，去除实验部位的肌肉组织，并临床测量测试部位和对照部位增容骨的高度和体积。在组织学上，在实验部位的脱钙垂直横切面上对骨组织进行形态计量学测量。结果发现，在增容骨的高度和体积方面，使用屏障覆盖骨移植颗粒具有统计学上的显著优势。
