Cellini M, Lodi R, Possati G L, Sbrocca M, Pelle D, Giubilei N
Université de Bologna, Istituto di Clinica Oculistica, Bologna, Italie.
J Fr Ophtalmol. 1997;20(9):659-63.
Retinitis pigmentosa is a bilateral retinal degeneration. The primary disorder is still debated.
We performed a prospective investigation of the ocular circulation directly by color Doppler imaging (CDI). A total of 28 eyes of 14 patients (8 men and 6 women, affected with retinitis pigmentosa) were recruited for this study. For each case were evaluated protosystolic velocity and the resistive index of the ophthalmic artery, central retinal artery, posterior ciliary arteries and choroid. These values, furthermore, have been compared with a control group.
The results of the CDI in the group of RP and in the CG were: in the OA: PSV 31.177 +/- 5.119 cm/sec vs 36.700 +/- 3.152 cm/sec (p < 0.007); RI 0.713 +/- 0.058 vs 0.717 +/- 0.019 (p < 0.0839); in the CRA PSV 7.075 +/- 1.611 cm/sec vs 12.710 +/- 2.795 cm/sec (p < 0.001); RI 0.560 +/- 0.062 vs 0.550 +/- 0.051 (p < 0.234); in the PCA: PSV 8.569 +/- 3.408 cm/sec vs 14.100 +/- 2.571 cm/sec (p < 0.001) with RI 0.634 +/- 0.090 vs 0.681 +/- 0.045 (p < 0.145). In the CHO: PSV 12.312 +/- 2.327 cm/sec vs 16.170 +/- 1.846 cm/sec (p < 0.001) with RI 0.581 +/- 0.072 vs 0.638 +/- 0.050 (p < 0.065).
Our results suggest that in the affected eyes there is a statistically significant reduction in blood flow in ophthalmic and ciliary arteries. These data offer new views on the retinitis cause of pigmentosa and possible therapeutics to be studied.
色素性视网膜炎是一种双侧性视网膜变性。其原发性疾病仍存在争议。
我们通过彩色多普勒成像（CDI）对眼部循环进行了前瞻性研究。本研究共纳入14例色素性视网膜炎患者（8例男性，6例女性）的28只眼睛。对每例患者的眼动脉、视网膜中央动脉、睫状后动脉和脉络膜的收缩期前速度和阻力指数进行评估。此外，还将这些值与一个对照组进行了比较。
色素性视网膜炎组和对照组的CDI结果如下：在眼动脉中：收缩期前速度（PSV）为31.177±5.119厘米/秒，对照组为36.700±3.152厘米/秒（p<0.007）；阻力指数（RI）为0.713±0.058，对照组为0.717±0.019（p<0.0839）；在视网膜中央动脉中，PSV为7.075±1.611厘米/秒，对照组为12.710±2.795厘米/秒（p<0.001）；RI为0.560±0.062，对照组为0.550±0.051（p<0.234）；在睫状后动脉中：PSV为8.569±3.408厘米/秒，对照组为14.100±2.571厘米/秒（p<0.001），RI为0.634±0.090，对照组为0.681±0.045（p<0.145）。在脉络膜中：PSV为12.312±2.327厘米/秒，对照组为16.170±1.846厘米/秒（p<0.001），RI为0.581±0.072，对照组为0.638±0.050（p<0.065）。
我们的结果表明，患眼中眼动脉和睫状动脉的血流在统计学上有显著减少。这些数据为色素性视网膜炎的病因及可能的治疗方法研究提供了新的观点。
