Kahane S, Greenberg D, Friedman M G, Haikin H, Dagan R
Department of Virology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
J Infect Dis. 1998 May;177(5):1425-9. doi: 10.1086/517830.
The newly described microorganism "Simkania Z" ("Z"), an obligate intracellular, penicillin-resistant microorganism most closely related to the chlamydiae, has been associated with adult community-acquired pneumonia. The possible involvement of "Z" in bronchiolitis in infants was examined in a prospective study of 239 infants with bronchiolitis and 78 controls. Other potential etiologic agents sought were respiratory syncytial virus (RSV), adenovirus, and cytomegalovirus. Evidence for the presence of "Z" in nasopharyngeal wash specimens (polymerase chain reaction and/or culture) was found in 25% of infants with bronchiolitis, while controls were all negative (P < .001). A serum IgA response to "Z" infection was detected by immunoperoxidase assay in 15% of infants with bronchiolitis versus 1.3% of controls (P < .001). Clinical findings were not different for infants with bronchiolitis associated with RSV alone, "Z" alone, or RSV and "Z" together. The high prevalence of "Z" in infants with bronchiolitis, often accompanied by an immune response, suggests a possible etiologic role of this agent in the disease.
新发现的微生物“辛卡尼亚Z菌”（“Z菌”）是一种专性细胞内寄生、对青霉素耐药的微生物，与衣原体最为密切相关，它已被证实与成人社区获得性肺炎有关。在一项针对239例患细支气管炎的婴儿和78例对照的前瞻性研究中，对“Z菌”在婴儿细支气管炎中的可能作用进行了研究。其他潜在的病原体包括呼吸道合胞病毒（RSV）、腺病毒和巨细胞病毒。在25%的患细支气管炎的婴儿的鼻咽冲洗标本中发现了“Z菌”存在的证据（聚合酶链反应和/或培养），而对照组均为阴性（P <.001）。通过免疫过氧化物酶测定法，在15%的患细支气管炎的婴儿中检测到了针对“Z菌”感染的血清IgA反应，而对照组为1.3%（P <.001）。仅与RSV相关、仅与“Z菌”相关或同时与RSV和“Z菌”相关的患细支气管炎的婴儿的临床发现并无差异。“Z菌”在患细支气管炎的婴儿中普遍存在，且常伴有免疫反应，这表明该病原体在该病中可能具有病因学作用。
