青霉素与克林霉素不同组合对四株化脓性链球菌的体外抗菌作用
In vitro antimicrobial effects of various combinations of penicillin and clindamycin against four strains of Streptococcus pyogenes.
作者信息
Stevens D L, Madaras-Kelly K J, Richards D M
机构信息
Infectious Diseases Section, VA Medical Center, Boise, Idaho 83702, USA.
出版信息
Antimicrob Agents Chemother. 1998 May;42(5):1266-8. doi: 10.1128/AAC.42.5.1266.
Abstract
Previous studies using mouse models of Streptococcus pyogenes necrotizing fasciitis demonstrated that clindamycin had greater efficacy than penicillin. Frequently both agents are used concurrently in the treatment of severe S. pyogenes infections. This study investigated interactions between penicillin and clindamycin. E-test and broth microdilution assays suggested additivity or indifference, while timed-killing assays demonstrated concentration-dependent variable effects. Timed-kill studies utilizing clinical concentrations suggest that there is no antagonism with the combination of drugs but that the combination does not have a bactericidal advantage over either penicillin or clindamycin alone.
摘要
先前使用化脓性链球菌坏死性筋膜炎小鼠模型的研究表明，克林霉素比青霉素具有更高的疗效。在治疗严重的化脓性链球菌感染时，这两种药物经常同时使用。本研究调查了青霉素与克林霉素之间的相互作用。E试验和肉汤微量稀释试验表明为相加或无关作用，而时间杀菌试验显示出浓度依赖性可变效应。利用临床浓度进行的时间杀菌研究表明，联合用药不存在拮抗作用，但联合用药并不比单独使用青霉素或克林霉素具有杀菌优势。
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