Léonard A
Radiat Environ Biophys. 1976 Mar 30;13(1):1-8. doi: 10.1007/BF01323617.
The observation of dividing spermatocytes is routinely used to detect the induction of heritable chromosome aberrations such as reciprocal translocations in the treated animals or in their F1 offspring. 37 compounds have so far been tested for the induction of chromosome rearrangements in spermatogonia. Only 9 gave positive results. However, positive results were observed for all alkylating agents in the F1 test. From these observations it can be concluded that the spermatogonia which are the main germ cell type at risk represent a relatively safe germ cell stage.
观察分裂中的精母细胞通常用于检测经处理的动物或其F1代后代中可遗传染色体畸变（如相互易位）的诱导情况。迄今为止，已对37种化合物进行了精原细胞染色体重排诱导作用的测试。只有9种得到了阳性结果。然而，在F1代测试中，所有烷化剂都得到了阳性结果。从这些观察结果可以得出结论，作为主要风险生殖细胞类型的精原细胞代表了一个相对安全的生殖细胞阶段。
