酷似斑秃的头皮转移瘤。胎盘部位滋养细胞肿瘤表现为皮肤转移的首例病例报告。
Scalp metastases mimicking alopecia areata. First case report of placental site trophoblastic tumor presenting as cutaneous metastasis.
作者信息
Yuen Y F, Lewis E J, Larson J T, Wilke M S, Rest E B, Zachary C B
机构信息
Department of Dermatology, University of Minnesota, Minneapolis, USA.
出版信息
Dermatol Surg. 1998 May;24(5):587-91.
BACKGROUND
Placental site trophoblastic tumor (PSTT) is a rare neoplasm of intermediate trophoblastic cells of the placenta. There is a wide range of biologic behavior, with metastases occurring in about 15% of cases. Cases with metastases have all presented with abnormal vaginal bleeding or gynecological symptoms.
METHODS
We describe a 31-year-old G3P3003 woman who presented with several alopecic patches resembling alopecia areata, which on biopsy proved to be metastatic, previously unsuspected, PSTT.
CONCLUSIONS
This represents the first case in which PSTT presented initially with metastases, and specifically, with cutaneous metastases. A new primary tumor source of alopecia neoplastica is presented. The role of mitotic counts in predicting prognosis in PSTT is supported. Alopecia areata was mimicked very closely. Dermatologists should be alert to any features atypical of alopecia areata, including erythema, induration, or palpability, and maintain a low threshold for biopsy in atypical cases.
背景
胎盘部位滋养细胞肿瘤（PSTT）是一种罕见的胎盘中间型滋养细胞肿瘤。其生物学行为范围广泛，约15%的病例会发生转移。发生转移的病例均表现为异常阴道出血或妇科症状。
方法
我们描述了一名31岁、孕3产3（G3P3）003的女性，她出现了几块类似斑秃的脱发斑，活检证实为转移性、此前未被怀疑的PSTT。
结论
这是首例最初以转移表现，特别是皮肤转移表现的PSTT病例。提出了一种新的肿瘤性脱发的原发肿瘤来源。支持有丝分裂计数在预测PSTT预后中的作用。该病例非常酷似斑秃。皮肤科医生应警惕斑秃的任何非典型特征，包括红斑、硬结或可触及性，对于非典型病例应保持较低的活检阈值。
Zotero 插件