Salvatore M J, King A B, Graham A C, Onishi H R, Bartizal K F, Abruzzo G K, Gill C J, Ramjit H G, Pitzenberger S M, Witherup K M
Merck Research Laboratories, Rahway, New Jersey 07065, USA.
J Nat Prod. 1998 May;61(5):640-2. doi: 10.1021/np9703961.
Lonchocarpol A, a flavanone, demonstrates in vitro inhibitory activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium. This activity is antagonized by mouse plasma, which may account for its lack of in vivo activity. This compound demonstrates no differentiation with respect to the inhibition of RNA, DNA, cell wall, and protein synthesis.
豆荚黄烷酮A，一种黄烷酮，在体外对耐甲氧西林金黄色葡萄球菌和耐万古霉素粪肠球菌具有抑制活性。这种活性被小鼠血浆拮抗，这可能是其缺乏体内活性的原因。该化合物在抑制RNA、DNA、细胞壁和蛋白质合成方面没有差异。
