第五种人类巨细胞病毒糖蛋白B基因型。
A fifth human cytomegalovirus glycoprotein B genotype.
作者信息
Shepp D H, Match M E, Lipson S M, Pergolizzi R G
机构信息
Department of Medicine, New York University School of Medicine, Manhasset 11030, USA.
出版信息
Res Virol. 1998 Mar-Apr;149(2):109-14. doi: 10.1016/s0923-2516(98)80086-1.
Genetic variation in glycoprotein B (gB) may play a role in human cytomegalovirus (HCMV) pathogenesis. Using restriction endonuclease digestion and DNA sequencing, a unique gB genotype was identified in eight HCMV strains isolated from five patients with the acquired immune deficiency syndrome. Nucleic acid homology to the four previously described gB genotypes ranged from 79 to 91% for the two major variable regions of gB. Studies of the role of gB in HCMV pathogenesis should recognize the existence of live gB genotypes.
糖蛋白B（gB）的基因变异可能在人巨细胞病毒（HCMV）发病机制中起作用。通过限制性内切酶消化和DNA测序，在从五名获得性免疫缺陷综合征患者分离出的八株HCMV毒株中鉴定出一种独特的gB基因型。gB两个主要可变区与先前描述的四种gB基因型的核酸同源性在79%至91%之间。关于gB在HCMV发病机制中作用的研究应认识到存在多种gB基因型。
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