Bertelli A A, Giovannini L, Stradi R, Urien S, Tillement J P, Bertelli A
Institute of Anatomy, University of Milan, Milan, Italy.
Drugs Exp Clin Res. 1998;24(1):51-5.
In view of the increasing interest in the biological activity of resveratrol, one of the components of red wine which is considered to be one of the main ingredients responsible for the beneficial effect of wine on human health, we have studied plasma kinetics and tissue bioavailability of this compound after red wine oral administration in rats. Plasma pharmacokinetics after oral administration of resveratrol could be described by an open one- or two-compartment model. Tissue concentrations show a significant cardiac bioavailability, and a strong affinity for the liver and kidneys.
鉴于人们对白藜芦醇生物活性的兴趣日益增加，白藜芦醇是红酒的成分之一，被认为是红酒对人体健康产生有益作用的主要成分之一，我们研究了大鼠口服红酒后该化合物的血浆动力学和组织生物利用度。口服白藜芦醇后的血浆药代动力学可用开放的一室或二室模型来描述。组织浓度显示出显著的心脏生物利用度，以及对肝脏和肾脏的强亲和力。
