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利用裂解性噬菌体控制鸡和犊牛实验性大肠杆菌败血症和脑膜炎

Use of lytic bacteriophage for control of experimental Escherichia coli septicemia and meningitis in chickens and calves.

作者信息

Barrow P, Lovell M, Berchieri A

机构信息

Institute for Animal Health, Compton Laboratory, Berkshire, United Kingdom.

出版信息

Clin Diagn Lab Immunol. 1998 May;5(3):294-8. doi: 10.1128/CDLI.5.3.294-298.1998.

Abstract

A lytic bacteriophage, which was previously isolated from sewage and which attaches to the K1 capsular antigen, has been used to prevent septicemia and a meningitis-like infection in chickens caused by a K1+ bacteremic strain of Escherichia coli. Protection was obtained even when administration of the phage was delayed until signs of disease appeared. The phage was able to multiply in the blood. In newly borne colostrum-deprived calves given the E. coli orally, intramuscular inoculation of phage delayed appearance of the bacterium in the blood and lengthened life span. With some provisos there is considerable potential for this approach to bacterial-disease therapy.

摘要

一种先前从污水中分离出来并附着于K1荚膜抗原的溶菌性噬菌体,已被用于预防由大肠杆菌K1 +菌血症菌株引起的鸡败血症和类脑膜炎感染。即使在疾病症状出现后才延迟施用噬菌体,也能获得保护效果。该噬菌体能够在血液中繁殖。在口服大肠杆菌的新生无初乳犊牛中,肌肉注射噬菌体可延迟细菌在血液中的出现并延长寿命。在一些条件下,这种细菌疾病治疗方法具有相当大的潜力。

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