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家禽生产中的抗菌药物耐药性:现状与细菌控制的创新策略

Antimicrobial Drug Resistance in Poultry Production: Current Status and Innovative Strategies for Bacterial Control.

作者信息

Abreu Raquel, Semedo-Lemsaddek Teresa, Cunha Eva, Tavares Luís, Oliveira Manuela

机构信息

CIISA-Centro de Investigação Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterinária, Universidade de Lisboa, Avenida da Universidade Técnica, 1300-477 Lisboa, Portugal.

Laboratório Associado para Ciência Animal e Veterinária (AL4AnimalS), 1300-477 Lisboa, Portugal.

出版信息

Microorganisms. 2023 Apr 6;11(4):953. doi: 10.3390/microorganisms11040953.

Abstract

The world population's significant increase has promoted a higher consumption of poultry products, which must meet the specified demand while maintaining their quality and safety. It is well known that conventional antimicrobials (antibiotics) have been used in livestock production, including poultry, as a preventive measure against or for the treatment of infectious bacterial diseases. Unfortunately, the use and misuse of these compounds has led to the development and dissemination of antimicrobial drug resistance, which is currently a serious public health concern. Multidrug-resistant bacteria are on the rise, being responsible for serious infections in humans and animals; hence, the goal of this review is to discuss the consequences of antimicrobial drug resistance in poultry production, focusing on the current status of this agroeconomic sector. Novel bacterial control strategies under investigation for application in this industry are also described. These innovative approaches include antimicrobial peptides, bacteriophages, probiotics and nanoparticles. Challenges related to the application of these methods are also discussed.

摘要

世界人口的显著增长推动了家禽产品消费量的增加,这些产品必须在保持质量和安全的同时满足特定需求。众所周知,传统抗菌剂(抗生素)已用于包括家禽在内的畜牧业生产,作为预防或治疗传染性细菌疾病的措施。不幸的是,这些化合物的使用和滥用导致了抗菌药物耐药性的产生和传播,这目前是一个严重的公共卫生问题。多重耐药细菌正在增加,导致人类和动物发生严重感染;因此,本综述的目的是讨论家禽生产中抗菌药物耐药性的后果,重点关注这个农业经济部门的现状。还描述了正在研究的用于该行业的新型细菌控制策略。这些创新方法包括抗菌肽、噬菌体、益生菌和纳米颗粒。还讨论了与这些方法应用相关的挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58fb/10141167/b38f60bc6670/microorganisms-11-00953-g001.jpg

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