一种大麻转移酶对橄榄酸进行异戊烯化反应生成大麻二酚酸，即四氢大麻酚的前体。
Prenylation of olivetolate by a hemp transferase yields cannabigerolic acid, the precursor of tetrahydrocannabinol.
作者信息
Fellermeier M, Zenk M H
机构信息
Lehrstuhl für Pharmazeutische Biologie, Ludwig-Maximilians-Universität München, Germany.
出版信息
FEBS Lett. 1998 May 8;427(2):283-5. doi: 10.1016/s0014-5793(98)00450-5.
PMID:9607329
Abstract
A new enzyme, geranylpyrophosphate:olivetolate geranyltransferase (GOT), the first enzyme in the biosynthesis of cannabinoids could be detected in extracts of young leaves of Cannabis sativa. The enzyme accepts geranylpyrophosphate (GPP) and to a lesser degree also nerylpyrophosphate (NPP) as a cosubstrate. It is, however, specific for olivetolic acid; its decarboxylation product olivetol is inactive as a prenyl acceptor.
摘要
一种新的酶，香叶基焦磷酸：橄榄酸香叶基转移酶（GOT），大麻素生物合成中的第一种酶，可在大麻幼叶提取物中检测到。该酶接受香叶基焦磷酸（GPP），在较小程度上也接受橙花基焦磷酸（NPP）作为共底物。然而，它对橄榄酸具有特异性；其脱羧产物橄榄醇作为异戊烯基受体无活性。
Zotero 插件