Begleiter H, Porjesz B, Reich T, Edenberg H J, Goate A, Blangero J, Almasy L, Foroud T, Van Eerdewegh P, Polich J, Rohrbaugh J, Kuperman S, Bauer L O, O'Connor S J, Chorlian D B, Li T K, Conneally P M, Hesselbrock V, Rice J P, Schuckit M A, Cloninger R, Nurnberger J, Crowe R, Bloom F E
Department of Psychiatry, SUNY Health Science Center at Brooklyn, NY 11203, USA.
Electroencephalogr Clin Neurophysiol. 1998 Apr;108(3):244-50. doi: 10.1016/s0168-5597(98)00002-1.
The P3 event-related brain potential (ERP) is a positive-going voltage change of scalp-recorded electroencephalographic activity that occurs between 300-500 ms after stimulus onset. It is elicited when a stimulus is perceived, memory operations are engaged, and attentional resources are allocated toward its processing. Because this ERP component reflects fundamental cognitive processing, it has found wide utility as an assessment of human mental function in basic and clinical studies. In particular, P3 attributes are heritable and have demonstrated considerable promise as a means to identify individuals at genetic risk for alcoholism. We have conducted a quantitative linkage analysis on a large sample from families with a high density of affected individuals. The analyses suggest that several regions of the human genome contain genetic loci related to the generation of the P3 component of the ERP, which are possible candidate loci underlying the functional organization of human neuroelectric activity.
P3事件相关脑电位（ERP）是头皮记录的脑电图活动中一种正向电压变化，出现在刺激开始后300 - 500毫秒之间。当刺激被感知、记忆操作被启动且注意力资源被分配用于其处理时会引发该电位。由于这个ERP成分反映了基本的认知加工过程，它在基础和临床研究中作为评估人类心理功能的方法已得到广泛应用。特别是，P3属性具有遗传性，并且作为识别有酒精中毒遗传风险个体的一种手段已显示出相当大的前景。我们对来自受影响个体高密度家庭的大样本进行了定量连锁分析。分析表明，人类基因组的几个区域包含与ERP的P3成分产生相关的基因位点，这些可能是人类神经电活动功能组织的潜在候选位点。
