Gogly B, Godeau G, Gilbert S, Legrand J M, Kut C, Pellat B, Goldberg M
Biology and Physiology Cranio-Facial Department, Faculty of Dental Surgery, University René Descartes, Paris V, Montrouge, France.
Clin Oral Investig. 1997 Sep;1(3):147-52. doi: 10.1007/s007840050026.
The morphometric parameters of the human gingival elastic fiber network were determined by image analysis and compared with human skin elastic fibers in relation to age. Similarly, collagen fibers were also investigated in both tissues. In this study, 47 healthy patients, 10-75 years old were studied for gingiva and another 50 patients in the same age range were included for skin biopsies. Three groups were compared: group 1 from the age of 10-24 years, group 2 from 25 to 49 years, and group 3 from 50 to 75 years. The diameters of the oxytalan fibers were invariable in both tissues, whatever the age considered. On the other hand, the diameters of elastic fibers increased regularly with age in the gingiva (P < 0.01) and in the skin (P < 0.01) between each age group. The area fraction occupied by the oxytalan fibers decreased significantly in both tissues (P < 0.01) for the skin and (P < 0.001) for the gingiva. The area fraction occupied by the gingival elastic fibers remained constant with age while the skin elastic fibers increased significantly with age between groups 2 and 1 (P < 0.01) and between groups 3 and 2 (P < 0.001). In the mid-dermis and in the mid-gingiva, the diameters of the collagen fibers increased strongly with age, between groups 2 and 1 (P < 0.01) and between groups 3 and 2 (P < 0.001). The area fraction occupied by the collagen bundles increased regularly with age in the mid-gingival (P < 0.05 between each age group), while a significant decrease was observed in the mid-dermis from the age of 50-75 years (P < 0.05). The results obtained contribute to a better understanding of some modifications which dermis and gingiva undergo with aging and provide data to perfect diagnosis and therapy in odontology and dermatology.
通过图像分析确定人类牙龈弹性纤维网络的形态计量学参数，并将其与不同年龄阶段的人类皮肤弹性纤维进行比较。同样，对两种组织中的胶原纤维也进行了研究。在本研究中，选取了47名年龄在10至75岁之间的健康患者进行牙龈研究，另外选取了50名同年龄范围的患者进行皮肤活检。比较了三组：第1组年龄在10至24岁之间，第2组年龄在25至49岁之间，第3组年龄在50至75岁之间。无论考虑何种年龄，两种组织中氧化弹力纤维的直径均无变化。另一方面，牙龈（P < 0.01）和皮肤（P < 0.01）中弹性纤维的直径随年龄在各年龄组之间呈规律性增加。氧化弹力纤维所占面积分数在皮肤中显著降低（P < 0.01），在牙龈中显著降低（P < 0.001）。牙龈弹性纤维所占面积分数随年龄保持恒定，而皮肤弹性纤维在第2组和第1组之间（P < 0.01）以及第3组和第2组之间（P < 0.001）随年龄显著增加。在真皮中部和牙龈中部，胶原纤维直径在第2组和第1组之间（P < 0.01）以及第3组和第2组之间（P < 0.001）随年龄大幅增加。牙龈中部胶原束所占面积分数随年龄有规律地增加（各年龄组之间P < 0.05），而在真皮中部从50至75岁开始观察到显著降低（P < 0.05）。所获得的结果有助于更好地理解真皮和牙龈随年龄发生的一些变化，并为完善牙科学和皮肤病学的诊断及治疗提供数据。
