Queiroz M L, Pena S C, Salles T S, de Capitani E M, Saad S T
Departamento de Farmacologia, Universidade Estadual de Campinas, SP, Brazil.
Hum Exp Toxicol. 1998 Apr;17(4):225-30. doi: 10.1177/096032719801700405.
To investigate the effects of chronic exposure to mercury we studied the red cell antioxidant system in mercury-exposed workers through the evaluation of reduced glutathione, catalase and superoxide dismutase systems. Of these workers, some were being exposed at the time and had presented urinary mercury levels considered safe for occupational exposure for at least 3 months prior to the initiation of this study, and others had been on leave for at least 6 months because of intoxication symptoms. Reduced glutathione levels were lower and catalase activity was higher in the workers which were still being exposed, compared to those on leave and controls. No differences were observed between the workers on leave and controls.
为了研究长期接触汞的影响，我们通过评估还原型谷胱甘肽、过氧化氢酶和超氧化物歧化酶系统，对接触汞的工人的红细胞抗氧化系统进行了研究。在这些工人中，一些人在研究开始前至少3个月一直处于接触状态，其尿汞水平被认为符合职业接触安全标准，另一些人则因中毒症状已休假至少6个月。与休假工人和对照组相比，仍在接触汞的工人的还原型谷胱甘肽水平较低而过氧化氢酶活性较高。休假工人和对照组之间未观察到差异。
