Ngan Kee W D
Department of Anaesthesia and Intensive Care, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong.
Anaesth Intensive Care. 1998 Jun;26(3):247-55. doi: 10.1177/0310057X9802600303.
Pethidine is an effective epidural opioid for the treatment of acute pain. Its use has been well described in Australian and New Zealand practice, particularly in the field of obstetric anaesthesia. Reported methods of delivery have included bolus injection, continuous infusion and patient-controlled epidural analgesia. Areas of application have included treatment of postoperative pain, labour pain and intraoperative pain. Because of its intermediate lipid solubility, pethidine may have advantages over many other epidural opioids. However, potential for accumulation of norpethidine limits its use to relatively short durations of treatment.
哌替啶是一种用于治疗急性疼痛的有效硬膜外阿片类药物。其在澳大利亚和新西兰的临床应用已有详细描述，尤其是在产科麻醉领域。报道的给药方法包括单次注射、持续输注和患者自控硬膜外镇痛。应用领域包括术后疼痛、分娩疼痛和术中疼痛的治疗。由于哌替啶具有中等脂溶性，它可能比许多其他硬膜外阿片类药物具有优势。然而，去甲哌替啶蓄积的可能性限制了其在相对较短治疗时间内的使用。
