van den Akker M, Buntinx F, Metsemakers J F, Roos S, Knottnerus J A
Department of General Practice, Maastricht University, The Netherlands.
J Clin Epidemiol. 1998 May;51(5):367-75. doi: 10.1016/s0895-4356(97)00306-5.
Increasing numbers of people are found to have two or more diseases at the same time, which is termed multimorbidity. We studied the prevalence, incidence, and determinants of multimorbidity and the statistical clustering of chronic and recurrent diseases in a general practice setting. Prevalence of multimorbidity increased with all age groups from 10% in the 0-19-year-old age group up to 78% in subjects aged 80 and over. Increasing age, lower level of education, and public health insurance were related to the occurrence of morbidity, but even more strongly to the occurrence and degree of multimorbidity. The one-year incidence of multimorbidity (the new occurrence of two or more diseases in one year) was related to increasing age, public health insurance, and the presence of prevalent diseases at baseline. Statistical clustering of diseases was stronger than expected, especially among the younger subjects.
越来越多的人被发现同时患有两种或更多种疾病，这被称为多病共存。我们在一个普通医疗环境中研究了多病共存的患病率、发病率、决定因素以及慢性和复发性疾病的统计聚类情况。多病共存的患病率在所有年龄组中都有所增加，从0至19岁年龄组的10%上升到80岁及以上人群的78%。年龄增长、教育水平较低和参加公共医疗保险与发病有关，但与多病共存的发生和程度关联更强。多病共存的一年发病率（一年内新出现两种或更多种疾病）与年龄增长、公共医疗保险以及基线时存在的流行疾病有关。疾病的统计聚类比预期更强，尤其是在较年轻的受试者中。
