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肌肉萎缩症的治疗试验。1. 小鼠萎缩症中的金标准。

Therapeutic trials in muscular dystrophy. 1. Gold in murine dystrophy.

作者信息

Enomoto A, Bradley W G

出版信息

J Neurol Neurosurg Psychiatry. 1978 May;41(5):404-7. doi: 10.1136/jnnp.41.5.404.

DOI:10.1136/jnnp.41.5.404
PMID:96218
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC493045/
Abstract

A trial of sodium aurothiomalate as an antiproteinase drug in the treatment of murine muscular dystrophy is reported. A blind controlled comparison of high (25 microgram/10 g body weight) and low dose gold (5 microgram/10 g body weight) with saline-injected control animals was made, all injections being given three times weekly. The body weights and functional ability of the mice were assessed at weekly intervals. No significant difference between the groups was observed. A trial of very high dose chrysotherapy (500 microgram of gold/10 g body weight) also showed no therapeutic benefit.

摘要

报道了一项关于硫代苹果酸金钠作为抗蛋白酶药物治疗小鼠肌肉萎缩症的试验。对高剂量（25微克/10克体重）和低剂量金（5微克/10克体重）的小鼠与注射生理盐水的对照动物进行了盲法对照比较，所有注射均每周进行三次。每周对小鼠的体重和功能能力进行评估。各实验组之间未观察到显著差异。一项极高剂量金疗法（500微克金/10克体重）的试验也未显示出治疗效果。

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本文引用的文献

1
Biochemistry of dystrophic muscle. 2. Some enzyme changes in dystrophic mouse muscle.营养不良性肌肉的生物化学。2. 营养不良小鼠肌肉中的一些酶变化。
Biochem J. 1963 Jul;88(1):64-8. doi: 10.1042/bj0880064.
2
Increased lysosomal enzymes in genetic muscular dystrophy.遗传性肌肉萎缩症中溶酶体酶增加。
Arch Biochem Biophys. 1962 Feb;96:340-6. doi: 10.1016/0003-9861(62)90418-6.
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Enzyme studies in muscular dystrophy. III. In hereditary muscular dystrophy in mice.肌肉萎缩症的酶学研究。III. 小鼠遗传性肌肉萎缩症
Proc Soc Exp Biol Med. 1958 Oct;99(1):272-6. doi: 10.3181/00379727-99-24320.
4
Gold in the treatment of rheumatoid arthritis.金制剂在类风湿关节炎治疗中的应用。
J Am Med Assoc. 1958 Jul 5;167(10):1204-7. doi: 10.1001/jama.1958.02990270010003.
5
Increasing the effectiveness of gold therapy in rheumatoid arthritis.提高金疗法在类风湿性关节炎中的疗效。
J Am Med Assoc. 1958 Jul 5;167(10):1197-204. doi: 10.1001/jama.1958.02990270003002.
6
Distribution and excretion of radiogold in animals.放射性金在动物体内的分布与排泄
Ann Rheum Dis. 1958 Mar;17(1):52-60. doi: 10.1136/ard.17.1.52.
7
Transport of gold in the body.体内金的转运。
Ann Rheum Dis. 1969 Jul;28(4):437-42. doi: 10.1136/ard.28.4.437.
8
Inhibition of human granulocyte elastase by gold sodium thiomalate.硫代苹果酸金钠对人粒细胞弹性蛋白酶的抑制作用。
Biochem Pharmacol. 1970 Feb;19(2):626-8. doi: 10.1016/0006-2952(70)90222-4.
9
Tissue gold concentration in a rheumatoid arthritic receiving chrysotherapy.接受金疗法的类风湿性关节炎患者的组织金浓度。
Arthritis Rheum. 1972 Jan-Feb;15(1):16-22. doi: 10.1002/art.1780150103.
10
Gold metabolism in patients with rheumatoid arthritis treated with gold compounds--reinvestigated.重新研究使用金化合物治疗的类风湿关节炎患者的金代谢情况。
Arthritis Rheum. 1972 Jul-Aug;15(4):391-402. doi: 10.1002/art.1780150410.

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