伴有破骨细胞样巨细胞的乳腺浸润性小叶癌。病例报告。
Invasive lobular carcinoma of the breast with osteoclastlike giant cells. A case report.
作者信息
Takahashi T, Moriki T, Hiroi M, Nakayama H
机构信息
Department of Clinical Laboratory, Kochi Medical School, Japan.
出版信息
Acta Cytol. 1998 May-Jun;42(3):734-41. doi: 10.1159/000331836.
BACKGROUND
Cytologic descriptions of invasive lobular carcinoma of the breast with osteoclastlike giant cells (OGCs) are exceedingly rare. Clinically, breast carcinoma with OGCs can be confused with fibroadenoma. The histogenesis of OGCs has been the subject of debate.
CASE
A 48-year-old female presented with a 1.5-cm, well-demarcated, firm, non-tender, mass involving the right breast. Fine needle aspiration biopsy (FNAB) showed the characteristic combination of relatively small, uniform carcinoma cells containing conspicuous intracytoplasmic lumina and numerous reactive multinucleated giant cells. OGCs were reactive for KP-1 and not stained with MIB-1.
CONCLUSION
The cytologic appearance of invasive lobular carcinoma with OGCs is characteristic. FNAB permits diagnosis of this rare type of breast carcinoma. Our study supported a histiocytic nature of the OGCs. OGCs were considered not actively proliferated cells.
背景
伴有破骨细胞样巨细胞（OGCs）的乳腺浸润性小叶癌的细胞学描述极为罕见。临床上，伴有OGCs的乳腺癌可能会与纤维腺瘤混淆。OGCs的组织发生一直是争论的焦点。
病例
一名48岁女性，右乳出现一个1.5厘米、边界清晰、质地坚硬、无压痛的肿块。细针穿刺活检（FNAB）显示出特征性组合，即相对较小、形态一致的癌细胞，胞质内可见明显的腔隙，以及大量反应性多核巨细胞。OGCs对KP-1呈阳性反应，而MIB-1染色阴性。
结论
伴有OGCs的浸润性小叶癌的细胞学表现具有特征性。FNAB有助于诊断这种罕见类型的乳腺癌。我们的研究支持OGCs具有组织细胞性质。OGCs被认为不是活跃增殖的细胞。
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