Gueirard P, Le Blay K, Le Coustumier A, Chaby R, Guiso N
Laboratoire des Bordetella, Institut Pasteur, Paris, France.
FEMS Microbiol Lett. 1998 May 15;162(2):331-7. doi: 10.1111/j.1574-6968.1998.tb13017.x.
We previously reported the case of a human chronic Bordetella bronchiseptica respiratory infection, due to contact with infected rabbits. Lipopolysaccharides of the human isolates, of one rabbit isolate and of isolate from other origins were analyzed with sera from infected mice, rabbit and human. Antigenicity and length of the lipopolysaccharide molecules varied between isolates. We showed a progressive loss of O-chain during infection, associated with an enhanced susceptibility of the isolates to the bactericidal effect of normal serum. This observation suggests the existence of an intracellular niche which selects for strains with distinct lipopolysaccharide types.
我们之前报道过一例因接触感染兔子而导致的人类支气管败血波氏杆菌慢性呼吸道感染病例。用人源分离株、一株兔源分离株以及其他来源的分离株的脂多糖，与感染小鼠、兔子和人类的血清进行分析。各分离株的脂多糖分子的抗原性和长度有所不同。我们发现感染过程中O抗原链逐渐缺失，同时分离株对正常血清杀菌作用的敏感性增强。这一观察结果表明存在一个细胞内微环境，它会选择具有不同脂多糖类型的菌株。
