Kato M, Kajimura N, Sekimoto M, Watanabe T, Takahashi K
National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
Psychiatry Clin Neurosci. 1998 Apr;52(2):262-3. doi: 10.1111/j.1440-1819.1998.tb01065.x.
We tried melatonin treatment in two patients with non-24 h sleep-wake syndrome, who did not respond to treatments by vitamin B12, bright light therapy, or hypnotics. In one patient, melatonin 5-10 mg improved difficulty in falling asleep and in waking, although it failed to improve the sleep-wake rhythm. In another patient, melatonin 3 mg successfully changed the sleep-wake rhythm from free-running pattern to delayed sleep phase pattern. However, melatonin re-administration after a 4-month drug-free interval failed to improve his free-running sleep-wake rhythm. These results suggest that melatonin acted as a sleep inducer in one patient and as a phase setter in the other, although the effect on the latter patient was transient.
我们对两名非24小时睡眠-清醒综合征患者进行了褪黑素治疗，这两名患者对维生素B12、强光疗法或催眠药治疗均无反应。在一名患者中，5-10毫克的褪黑素改善了入睡困难和觉醒困难，尽管它未能改善睡眠-清醒节律。在另一名患者中，3毫克的褪黑素成功地将睡眠-清醒节律从自由运行模式转变为延迟睡眠相位模式。然而，在4个月的无药间隔后重新服用褪黑素未能改善他的自由运行睡眠-清醒节律。这些结果表明，褪黑素在一名患者中起到了睡眠诱导剂的作用，而在另一名患者中起到了相位设定剂的作用，尽管对后一名患者的影响是短暂的。
