香港不同社会经济群体的粪便类固醇、细菌与大肠癌
Faecal steroids and bacteria and large bowel cancer in Hong Kong by socio-economic groups.
作者信息
Crowther J S, Drasar B S, Hill M J, Maclennan R, Magnin D, Peach S, Teoh-chan C H
出版信息
Br J Cancer. 1976 Aug;34(2):191-8. doi: 10.1038/bjc.1976.142.
Abstract
In a study of three socio-economic groups in Hong Kong, the high income group had a high faecal concentration of bile acids, especially the dihydroxy bile acids, compared to the low income group. The faecal bile acids were also more highly degraded. The faecal flora contained more bacteroides and fewer eubacteria. Very few of the clostridia able to dehydrogenate the steroid nucleus were isolated. An epidemiological study based on street blocks indicated that the high income group also have a higher incidence of cancer of the large bowel and of the breast. The results are discussed in terms of theories on the aetiology of large bowel cancer.
摘要
在一项针对香港三个社会经济群体的研究中，与低收入群体相比，高收入群体粪便中的胆汁酸浓度较高，尤其是二羟基胆汁酸。粪便中的胆汁酸降解程度也更高。粪便菌群中拟杆菌较多，真细菌较少。能够使类固醇核脱氢的梭状芽孢杆菌分离出来的很少。一项基于街区的流行病学研究表明，高收入群体患大肠癌和乳腺癌的发病率也较高。根据大肠癌病因学理论对结果进行了讨论。
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