Department of Cell Biology and Anatomy, College of Medicine, University of Arizona, Tucson, AZ 85724-5044, USA.
Arch Toxicol. 2011 Aug;85(8):863-71. doi: 10.1007/s00204-011-0648-7. Epub 2011 Jan 26.
High dietary fat causes increased bile acid secretion into the gastrointestinal tract and is associated with colon cancer. Since the bile acid deoxycholic acid (DOC) is suggested to be important in colon cancer etiology, this study investigated whether DOC, at a high physiologic level, could be a colon carcinogen. Addition of 0.2% DOC for 8-10 months to the diet of 18 wild-type mice induced colonic tumors in 17 mice, including 10 with cancers. Addition of the antioxidant chlorogenic acid at 0.007% to the DOC-supplemented diet significantly reduced tumor formation. These results indicate that a high fat diet in humans, associated with increased risk of colon cancer, may have its carcinogenic potential mediated through the action of bile acids, and that some dietary anti-oxidants may ameliorate this carcinogenicity.
高脂肪饮食会导致胆汁酸分泌增加进入胃肠道，并与结肠癌有关。由于胆汁酸脱氧胆酸（DOC）被认为在结肠癌发病机制中很重要，因此本研究探讨了高生理水平的 DOC 是否可能是结肠癌的致癌物质。在 18 只野生型小鼠的饮食中添加 0.2%的 DOC 8-10 个月，导致 17 只小鼠发生结肠肿瘤，其中 10 只发生癌症。在添加 DOC 的饮食中添加 0.007%的抗氧化剂绿原酸可显著减少肿瘤形成。这些结果表明，人类高脂肪饮食与结肠癌风险增加有关，其致癌潜能可能通过胆汁酸的作用介导，而某些饮食抗氧化剂可能减轻这种致癌性。
