Lane R J, Barrett M C, Taylor D J, Kemp G J, Lodi R
Division of Clinical Neuroscience and Psychological Medicine, Imperial College School of Medicine, Charing Cross Hospital, London, UK.
Neuromuscul Disord. 1998 May;8(3-4):204-9. doi: 10.1016/s0960-8966(98)00021-2.
It has been shown previously that some patients with chronic fatigue syndrome show an abnormal increase in plasma lactate following a short period of moderate exercise, in the sub-anaerobic threshold exercise test (SATET). This cannot be explained satisfactorily by the effects of 'inactivity' or 'deconditioning', and patients with abnormal lactate responses to exercise (SATET +ve) have been found to have significantly fewer Type 1 muscle fibres in quadriceps biopsies than SATET -ve patients. We performed phosphorus magnetic resonance spectroscopy on forearm muscles of 10 SATET +ve patients, 9 SATET -ve patients and 13 sedentary volunteers. There were no differences in resting spectra between these groups but at the end of exercise, intracellular pH in the SATET +ve patients was significantly lower than in both the SATET -ve cases and controls (P < 0.03), and the SATET +ve patients also showed a significantly lower ATP synthesis rate during recovery (P < 0.01), indicating impaired mitochondrial oxidative phosphorylation. These observations support other evidence which indicates that chronic fatigue syndrome is a heterogeneous disorder, and confirms the view that some chronic fatigue syndrome patients have a peripheral component to their fatigue.
先前已有研究表明，在亚无氧阈运动试验（SATET）中，一些慢性疲劳综合征患者在短时间适度运动后血浆乳酸会异常增加。这无法通过“缺乏运动”或“身体机能下降”的影响来令人满意地解释，并且已发现运动时乳酸反应异常（SATET阳性）的患者，其股四头肌活检中I型肌纤维明显少于SATET阴性患者。我们对10名SATET阳性患者、9名SATET阴性患者和13名久坐志愿者的前臂肌肉进行了磷磁共振波谱分析。这些组之间的静息波谱没有差异，但在运动结束时，SATET阳性患者的细胞内pH值显著低于SATET阴性患者和对照组（P < 0.03），并且SATET阳性患者在恢复过程中的ATP合成率也显著较低（P < 0.01），表明线粒体氧化磷酸化受损。这些观察结果支持了其他表明慢性疲劳综合征是一种异质性疾病的证据，并证实了一些慢性疲劳综合征患者的疲劳存在外周因素的观点。
