Sleight Alix G, Crowder Sylvia L, Skarbinski Jacek, Coen Paul, Parker Nathan H, Hoogland Aasha I, Gonzalez Brian D, Playdon Mary C, Cole Steven, Ose Jennifer, Murayama Yuichi, Siegel Erin M, Figueiredo Jane C, Jim Heather S L
Department of Physical Medicine & Rehabilitation, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Center for Integrated Research in Cancer and Lifestyle, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Cancers (Basel). 2022 Apr 14;14(8):1982. doi: 10.3390/cancers14081982.
A major gap impeding development of new treatments for cancer-related fatigue is an inadequate understanding of the complex biological, clinical, demographic, and lifestyle mechanisms underlying fatigue. In this paper, we describe a new application of a comprehensive model for cancer-related fatigue: the predisposing, precipitating, and perpetuating (3P) factors model. This model framework outlined herein, which incorporates the emerging field of metabolomics, may help to frame a more in-depth analysis of the etiology of cancer-related fatigue as well as a broader and more personalized set of approaches to the clinical treatment of fatigue in oncology care. Included within this review paper is an in-depth description of the proposed biological mechanisms of cancer-related fatigue, as well as a presentation of the 3P model's application to this phenomenon. We conclude that a clinical focus on organization risk stratification and treatment around the 3P model may be warranted, and future research may benefit from expanding the 3P model to understand fatigue not only in oncology, but also across a variety of chronic conditions.
阻碍癌症相关疲劳新疗法发展的一个主要差距在于，对疲劳背后复杂的生物学、临床、人口统计学和生活方式机制缺乏充分了解。在本文中，我们描述了一种癌症相关疲劳综合模型的新应用：易患、促发和持续（3P）因素模型。本文概述的这个模型框架纳入了新兴的代谢组学领域，可能有助于对癌症相关疲劳的病因进行更深入分析，并为肿瘤护理中疲劳的临床治疗提供一套更广泛、更个性化的方法。这篇综述文章深入描述了癌症相关疲劳的拟议生物学机制，以及3P模型在此现象中的应用。我们得出结论，围绕3P模型对组织风险分层和治疗进行临床关注可能是必要的，未来的研究可能会受益于扩展3P模型，以不仅在肿瘤学领域，而且在各种慢性疾病中理解疲劳。
