Lane R J, Barrett M C, Woodrow D, Moss J, Fletcher R, Archard L C
Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, Charing Cross Hospital, London, UK.
J Neurol Neurosurg Psychiatry. 1998 Mar;64(3):362-7. doi: 10.1136/jnnp.64.3.362.
To examine the proportions of type 1 and type 2 muscle fibres and the degree of muscle fibre atrophy and hypertrophy in patients with chronic fatigue syndrome in relation to lactate responses to exercise, and to determine to what extent any abnormalities found might be due to inactivity.
Quadriceps needle muscle biopsies were obtained from 105 patients with chronic fatigue syndrome and the proportions of type 1 and 2 fibres and fibre atrophy and hypertrophy factors were determined from histochemical preparations, using a semiautomated image analysis system. Forty one randomly selected biopsies were also examined by electron microscopy. Lactate responses to exercise were measured in the subanaerobic threshold exercise test (SATET).
Inactivity would be expected to result in a shift to type 2 fibre predominance and fibre atrophy, but type 1 predominance (23%) was more common than type 2 predominance (3%), and fibre atrophy was found in only 10.4% of cases. Patients with increased lactate responses to exercise did have significantly fewer type 1 muscle fibres (p<0.043 males, p<0.0003 females), but there was no evidence that this group was less active than the patients with normal lactate responses. No significant ultrastructural abnormalities were found.
Muscle histometry in patients with chronic fatigue syndrome generally did not show the changes expected as a result of inactivity. However, patients with abnormal lactate responses to exercise had a significantly lower proportion of mitochondria rich type 1 muscle fibres.
研究慢性疲劳综合征患者1型和2型肌纤维的比例以及肌纤维萎缩和肥大程度与运动乳酸反应的关系，并确定所发现的任何异常在多大程度上可能是由于缺乏运动所致。
对105例慢性疲劳综合征患者进行股四头肌针吸活检，使用半自动图像分析系统从组织化学标本中确定1型和2型纤维的比例以及纤维萎缩和肥大因子。还对41例随机选取的活检标本进行了电子显微镜检查。在亚无氧阈运动试验（SATET）中测量运动的乳酸反应。
预计缺乏运动会导致向2型纤维优势和纤维萎缩转变，但1型纤维优势（23%）比2型纤维优势（3%）更常见，且仅10.4%的病例发现有纤维萎缩。运动乳酸反应增加的患者1型肌纤维明显较少（男性p<0.043，女性p<0.0003），但没有证据表明该组患者比乳酸反应正常的患者活动量少。未发现明显的超微结构异常。
慢性疲劳综合征患者的肌肉组织测量通常未显示出因缺乏运动而预期出现的变化。然而，运动乳酸反应异常的患者富含线粒体的1型肌纤维比例明显较低。
