Wallace S, Wong T, Fernando W
Radiotherapy Physics Department, Austin and Repatriation Medical Centre, Heidelberg West, Vic.
Australas Phys Eng Sci Med. 1998 Mar;21(1):11-7.
This study examines the transverse radial dose distribution around the Nucletron MicroSelectron high dose rate (HDR) 192Ir brachytherapy source using the Monte Carlo radiation transport code MCNP (Monte Carlo N Particle) version 4A. The geometry modeled consisted of an identical simulation of the geometry of the MicroSelectron HDR source within the centre of a cylindrical water phantom of 80 cm diameter and height. Doses were calculated at 0.1 cm intervals in the 1 cm closest to the source, whilst extending to 1 cm intervals 15 cm from the source. Conversion to the clinically relevant unit of air-kerma strength to describe source activity enables absolute comparison of Monte Carlo dose calculations to current treatment planning computer results. Most HDR brachytherapy planning computers utilise algorithms based on a point source with attenuation and scatter corrections based on the Van Kleffen and Starr or Meisberger equations. Significant differences between the planning computer algorithms and the Monte Carlo dose calculations occur in the near field (radius less than 1 cm) and the far field (radius greater than 8 cm) which in some cases may have important clinical consequences. These results are consistent with Monte Carlo calculations of previous authors examining the MicroSelectron HDR 192Ir source and also show that far field uncertainties are increased as the size of the phantom is reduced to a more realistic patient size.
本研究使用蒙特卡罗辐射输运代码MCNP(蒙特卡罗N粒子)4A版,研究了Nucletron MicroSelectron高剂量率(HDR)192Ir近距离治疗源周围的横向径向剂量分布。所建立的几何模型是在一个直径和高度均为80 cm的圆柱形水体模中心,对MicroSelectron HDR源的几何结构进行相同的模拟。在最靠近源的1 cm范围内,以0.1 cm的间隔计算剂量,同时在距源15 cm处延伸至1 cm的间隔计算剂量。转换为描述源活度的临床相关空气比释动能强度单位,能够将蒙特卡罗剂量计算结果与当前治疗计划计算机的结果进行绝对比较。大多数HDR近距离治疗计划计算机使用基于点源的算法,并根据Van Kleffen和Starr或Meisberger方程进行衰减和散射校正。在近场(半径小于1 cm)和远场(半径大于8 cm)中,计划计算机算法与蒙特卡罗剂量计算之间存在显著差异,在某些情况下可能会产生重要的临床后果。这些结果与之前研究MicroSelectron HDR 192Ir源的作者的蒙特卡罗计算结果一致,并且还表明,当体模尺寸减小到更接近实际患者的尺寸时,远场的不确定性会增加。