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蒙特卡洛辅助的微型电子脉冲及高剂量率192铱源剂量测定法。

Monte Carlo aided dosimetry of the microselectron pulsed and high dose-rate 192Ir sources.

作者信息

Williamson J F, Li Z

机构信息

Radiation Oncology Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

出版信息

Med Phys. 1995 Jun;22(6):809-19. doi: 10.1118/1.597483.

Abstract

Despite the large number of single-stepping source pulsed and high dose-rate (HDR) remote after-loading devices in clinical use, the published literature contain little data characterizing dose-rate distributions around the high-intensity (4 x 10(3)-4 x 10(4) microGy m2h-1) 192Ir sources currently used in these devices. We have used the Monte Carlo method to calculate complete two-dimensional dose-rate distributions about the most widely used high dose-rate source design, as well as the Nucletron pulsed dose-rate (PDR) 192Ir source. A Monte Carlo photon transport code, incorporating the detailed internal geometry of the source, was used to calculate the dose rate per unit air-kerma strength in water medium on the transverse bisecting axis over the 0.15-12 cm distance range. In addition, polar dose profiles were calculated at distances ranging from 0.25 to 5 cm. The PDR and HDR dose-rate distributions are tabulated using the formalism endorsed by the Interstitial Collaborative Working Group and the AAPM Task Group 43, and includes dose-rate constant, radial dose function, anisotropy function, geometry function, and anisotropy factors. The dose-rate constants, lambda, of the MicroSelectron/HDR and PDR sources were found to be 1.115 and 1.128 cGy h-1 per unit air-kerma strength, respectively, in good agreement with previously published data for low dose-rate interstitial 192Ir sources. Oblique filtration by the high-density iridium metal core resulted in deviations from anisotropy as large as 35%-55% near the longitudinal axis of the source. Dose-rate distributions are also presented in Cartesian ("away" and "along") coordinates.

摘要

尽管临床使用的单步源脉冲和高剂量率(HDR)远程后装设备数量众多,但已发表的文献中几乎没有关于这些设备目前使用的高强度(4×10³ - 4×10⁴ μGy m²h⁻¹)¹⁹²Ir源周围剂量率分布的数据。我们使用蒙特卡罗方法计算了最广泛使用的高剂量率源设计以及核通脉冲剂量率(PDR)¹⁹²Ir源的完整二维剂量率分布。使用一个包含源详细内部几何结构的蒙特卡罗光子传输代码,计算在0.15 - 12 cm距离范围内横向平分轴上水中每单位空气比释动能强度的剂量率。此外,还计算了距离范围为0.25至5 cm的极坐标剂量分布。PDR和HDR剂量率分布按照间质协作工作组和美国医学物理师协会任务组43认可的形式列出,包括剂量率常数、径向剂量函数、各向异性函数、几何函数和各向异性因子。发现MicroSelectron/HDR和PDR源的剂量率常数λ分别为每单位空气比释动能强度1.115和1.128 cGy h⁻¹,与先前发表的低剂量率间质¹⁹²Ir源数据吻合良好。高密度铱金属芯的斜向过滤导致在源纵轴附近与各向异性的偏差高达35% - 55%。剂量率分布也以笛卡尔坐标(“远离”和“沿”)呈现。

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