Brueren M M, Schouten B J, Schouten H J, van Weel C, de Leeuw P W, van Ree J W
Department of General Practice, Maastricht University, The Netherlands.
Am J Hypertens. 1998 May;11(5):602-5. doi: 10.1016/s0895-7061(98)00019-3.
Our objective was to study seasonal influences on office and ambulatory blood pressure. We therefore designed a prospective 7-month study of 47 borderline hypertensive patients in a primary care setting. We used no interventions. Our main outcome measures were the differences between summer and winter office and ambulatory blood pressures and 95% confidence intervals. Results showed that winter minus summer differences ranged from 0 to 3 mm Hg. Only one significant difference was found: ambulatory systolic daytime pressure was significantly higher (3 mm Hg) in winter than in summer. Our results do not confirm the data of earlier studies in hypertensives. In view of the small and clinically irrelevant winter-summer differences, it seems unnecessary to modify antihypertensive treatment of borderline hypertensives according to the season.
我们的目的是研究季节对诊室血压和动态血压的影响。因此，我们在初级保健机构中对47例临界高血压患者进行了一项为期7个月的前瞻性研究。我们未采取任何干预措施。我们的主要观察指标是夏季和冬季诊室血压及动态血压之间的差异以及95%置信区间。结果显示，冬季与夏季的差值范围为0至3毫米汞柱。仅发现一个显著差异：动态收缩期日间血压在冬季显著高于夏季（3毫米汞柱）。我们的结果并未证实早期对高血压患者研究的数据。鉴于冬季与夏季的差异较小且与临床无关，似乎没有必要根据季节调整临界高血压患者的降压治疗。
