Fox P T, Parsons L M, Lancaster J L
Research Imaging Center, University of Texas Health Science Center at San Antonio 78284-6240, USA.
Curr Opin Neurobiol. 1998 Apr;8(2):178-87. doi: 10.1016/s0959-4388(98)80138-4.
Cognitive neuroimaging maps the brain locations of mental operations. This process is iterative, as no single study can fully characterize a mental operation or its brain location. This iterative discovery process, in combination with the location-reporting standard (i.e. spatial coordinates) of the cognitive neuroimaging community, has engendered a new form of metanalysis. Response locations from multiple studies have been analyzed collectively so as to better describe the spatial distribution of brain activations, with promising results. New hypotheses regarding elementary mental operations and their respective brain locations are being generated and refined via metanalysis. These hypotheses are being tested and confirmed by subsequent, prospective experiments. Function/location metanalysis is an important new tool for hypothesis generation in cognitive neuroimaging. This form of metanalysis is fundamentally different from the effect-size metanalyses prevalent in other literatures, with unique advantages and challenges.
认知神经成像描绘了心理活动在大脑中的位置。这个过程是迭代的，因为没有任何一项研究能够全面地描述一种心理活动或其在大脑中的位置。这种迭代发现过程，与认知神经成像学界的位置报告标准（即空间坐标）相结合，催生了一种新的元分析形式。来自多项研究的反应位置已经被集中分析，以便更好地描述大脑激活的空间分布，结果很有前景。关于基本心理活动及其各自大脑位置的新假设正在通过元分析产生并得到完善。这些假设正在通过后续的前瞻性实验进行检验和证实。功能/位置元分析是认知神经成像中生成假设的一种重要新工具。这种元分析形式与其他文献中普遍存在的效应量元分析有着根本的不同，具有独特的优势和挑战。
