Ghannoum M A, Abu-Elteen K H, Motawy M S
Department of Botany and Microbiology, Kuwait University, Safat.
Mycopathologia. 1988 Dec;104(3):171-80. doi: 10.1007/BF00437433.
The role of chemotherapy, X-irradiation and a combination of both on the phenomenon of adherence of yeast to buccal epithelial cells (BEC) was investigated in vitro. Growth of three Candida spp. in the presence of eight of eleven antineoplastic agents led to reduction of adherence of the isolates tested (reduction between 30% and 61% of the control value), and this effect was observed whether exponential or stationary phase Candida cells were used. Exposure of C. albicans to various doses of radiation also led to a reduction in adherence of this yeast to BEC between 31% and 53% of the control value. This reduction was shown to be dose related. Similar results were obtained when BEC were exposed to radiation, and the effects of radiation treatment was accentuated when both yeast and BEC were irradiated simultaneously. Furthermore, treating C. albicans with a combination of chemotherapy and radiation led to the greatest reduction in adherence of yeast to BEC compared to when the yeast was treated with either chemotherapy or radiation alone (reduction between 63% to 74% as compared with control). The possible mechanism/s involved in reduction of adherence of yeast to BEC are discussed.
体外研究了化疗、X射线照射以及二者联合对酵母与颊黏膜上皮细胞（BEC）黏附现象的作用。三种念珠菌属在11种抗肿瘤药物中的8种存在情况下生长，导致所测试分离株的黏附减少（减少幅度为对照值的30%至61%），无论使用指数期还是稳定期念珠菌细胞，均观察到这种效应。白色念珠菌暴露于不同剂量辐射也导致该酵母与BEC的黏附减少，减少幅度为对照值的31%至53%。这种减少显示与剂量相关。当BEC暴露于辐射时也获得了类似结果，并且当酵母和BEC同时照射时，辐射处理的效果会增强。此外，与单独用化疗或辐射处理酵母相比，用化疗和辐射联合处理白色念珠菌导致酵母与BEC的黏附减少幅度最大（与对照相比减少63%至74%）。讨论了酵母与BEC黏附减少可能涉及的机制。
