Pietruczuk M, Wasiluk A, Jaworski S, Dabrowska M
Zakładu Diagnostyki Hematologicznej, Instytut Diagnostyki Laboratoryjnej Akademii Medycznej w Białymstoku.
Ginekol Pol. 1998 Apr;69(4):182-7.
It has been observed that immunological reactivity of neonatal leukocytes is diminished. It seems to result from lymphocytes immaturity. In the present study we have evaluated the phenotype of cord blood lymphocytes with the use of flow cytometry. In neonates we have observed the increase in the absolute number of CD1a and CD7 positive lymphocytes as well as CD2, CD3, CD4, CD8, CD16, CD19 and CD20 positive, while number of CD57 positive cells was significantly decreased. The ratios of CD4/CD8 and T/B lymphocytes were similar to the corresponding ratios observed in adults. Our results have shown the presence of immature lymphocyte population as well quantitative depletion of subpopulation of CD57 cells, what may pose an increased risk of infection in neonates. Nevertheless, increased number of T and B lymphocytes with mature phenotype along with normal ratio of lymphocyte subpopulations and increased number of CD16 positive cells (NK cells), may explain phenomenon of good health among majority of newborns.
据观察，新生儿白细胞的免疫反应性会降低。这似乎是由于淋巴细胞不成熟所致。在本研究中，我们使用流式细胞术评估了脐血淋巴细胞的表型。在新生儿中，我们观察到CD1a和CD7阳性淋巴细胞以及CD2、CD3、CD4、CD8、CD16、CD19和CD20阳性淋巴细胞的绝对数量增加，而CD57阳性细胞的数量显著减少。CD4/CD8和T/B淋巴细胞的比例与在成年人中观察到的相应比例相似。我们的结果表明存在未成熟淋巴细胞群体以及CD57细胞亚群的定量减少，这可能会增加新生儿感染的风险。然而，具有成熟表型的T和B淋巴细胞数量增加以及淋巴细胞亚群比例正常和CD16阳性细胞（自然杀伤细胞）数量增加，可能解释了大多数新生儿健康状况良好的现象。
