Steiner M, Lin R S
Division of Hematology/Oncology, East Carolina University School of Medicine, Greenville, North Carolina 27858-4354, USA.
J Cardiovasc Pharmacol. 1998 Jun;31(6):904-8. doi: 10.1097/00005344-199806000-00014.
Garlic and some of its organosulfur components have been found to be potent inhibitors of platelet aggregation in vitro. Demonstration of their efficacy in vivo, however, especially when administered over extended periods, is sparse. We recently performed a 10-month study comparing the effect of aged garlic extract (AGE) with placebo on the lipid profiles of moderately hypercholesterolemic men. In the course of the intervention trial, we examined platelet functions and susceptibility of lipoproteins to oxidation in a subgroup of this study population. Study subjects supplemented with 7.2 AGE per day showed a significant reduction of epinephrine- and, to a lesser degree, collagen-induced platelet aggregation but failed to demonstrate an inhibition of adenosine diphosphate (ADP)-induced aggregation. Platelet adhesion to fibrinogen, measured in a laminar flow chamber at moderately high shear rate, was reduced by approximately 30% in subjects taking AGE compared with placebo supplement. A trend toward decreased susceptibility of lipoproteins to oxidation also was noted during AGE administration compared with the placebo period. We conclude that the beneficial effect of garlic preparations on lipids and blood pressure extends also to platelet function, thus providing a wider potential protection of the cardiovascular system.
大蒜及其一些有机硫成分在体外已被发现是血小板聚集的有效抑制剂。然而，关于它们在体内的功效，尤其是长期给药时的功效，相关证据却很少。我们最近进行了一项为期10个月的研究，比较了 aged garlic extract（AGE）与安慰剂对中度高胆固醇血症男性血脂水平的影响。在干预试验过程中，我们在该研究人群的一个亚组中检测了血小板功能以及脂蛋白对氧化的易感性。每天补充7.2 AGE的研究对象，其肾上腺素诱导的血小板聚集显著减少，胶原蛋白诱导的血小板聚集也有一定程度的减少，但对二磷酸腺苷（ADP）诱导的聚集未显示出抑制作用。与补充安慰剂的受试者相比，在中等高剪切速率下于层流室中测量，服用AGE的受试者血小板与纤维蛋白原的黏附减少了约30%。与安慰剂阶段相比，在服用AGE期间还观察到脂蛋白氧化易感性有降低的趋势。我们得出结论，大蒜制剂对血脂和血压的有益作用也扩展到了血小板功能，从而为心血管系统提供了更广泛的潜在保护。
