枯草芽孢杆菌四环素敏感菌株的tetA(L)突变体，其多核苷酸磷酸化酶基因已缺失。
tetA(L) mutants of a tetracycline-sensitive strain of Bacillus subtilis with the polynucleotide phosphorylase gene deleted.
作者信息
Bechhofer D H, Stasinopoulos S J
机构信息
Department of Biochemistry, Mount Sinai School of Medicine, City University of New York, New York 10029, USA.
出版信息
J Bacteriol. 1998 Jul;180(13):3470-3. doi: 10.1128/JB.180.13.3470-3473.1998.
Abstract
A Bacillus subtilis strain with the polynucleotide phosphorylase gene deleted was sensitive for growth in the presence of tetracycline. This strain was used to select for tetracycline-resistant mutants. A point mutation in the tetA(L) promoter and a spontaneously occurring tetA(L) gene copy number mutant were characterized.
摘要
一株缺失多核苷酸磷酸化酶基因的枯草芽孢杆菌菌株在四环素存在的情况下生长敏感。该菌株用于筛选四环素抗性突变体。对tetA(L)启动子中的一个点突变和一个自发产生的tetA(L)基因拷贝数突变体进行了表征。
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