Ridder G J, Maschek H, Flemming P, Nashan B, Klempnauer J
Clinic of Abdominal and Transplantation Surgery, Medizinische Hochschule Hannover, Germany.
Virchows Arch. 1998 May;432(5):451-4. doi: 10.1007/s004280050190.
A female patient with a mucinous cystadenocarcinoma originating from a mucinous cystadenoma of the pancreas is presented. The cystic tumour was diagnosed 3 years before and was treated with interventional external and internal surgical drainage before radical resection was accomplished by left hemipancreatectomy. Histology showed simultaneous occurrence of mildly dysplastic and invasive malignant epithelium. Immunohistology revealed inhibin-positive cells in the ovarianlike stroma of the tumour. The demonstration of ovarian-like stroma positive for inhibin suggests that this could be a hamartoma with dispersed sex-cord stroma, which would explain the predominance of the female gender in mucinous cystic tumours of the pancreas.
本文报告一例起源于胰腺黏液性囊腺瘤的黏液性囊腺癌女性患者。该囊性肿瘤3年前被诊断出来，在通过左半胰切除术完成根治性切除之前，先接受了介入性外引流和内引流治疗。组织学检查显示同时存在轻度发育异常和浸润性恶性上皮。免疫组织化学显示肿瘤的卵巢样间质中有抑制素阳性细胞。抑制素阳性的卵巢样间质的存在提示这可能是一种伴有散在性索间质的错构瘤，这可以解释胰腺黏液性囊性肿瘤中女性占优势的现象。
