Lagrost L, Desrumaux C, Masson D, Deckert V, Gambert P
Lipoprotein Biochemistry Laboratory, INSERM U498, Department of Medicine, Dijon, France.
Curr Opin Lipidol. 1998 Jun;9(3):203-9. doi: 10.1097/00041433-199806000-00004.
Recent cloning and sequencing of plasma phospholipid transfer protein complementary DNA revealed that phospholipid transfer protein belongs to the lipid transfer/lipopolysaccharide binding protein family that includes the cholesteryl ester transfer protein, the bactericidal permeability increasing protein and the lipopolysaccharide-binding protein. In addition to structural similarities, members of the lipid transfer/lipopolysaccharide-binding protein family might share some common functional properties, and recent studies demonstrated that phospholipid transfer protein can act in several distinct metabolic processes. In particular, the molecular transfer of phospholipids, unesterified cholesterol, alpha-tocopherol and lipopolysaccharides by phospholipid transfer protein suggests that it might be involved both in lipoprotein metabolism and in antimicrobial defence, resulting in a growing interest in this protein.
最近对血浆磷脂转运蛋白互补DNA的克隆和测序显示，磷脂转运蛋白属于脂质转运/脂多糖结合蛋白家族，该家族包括胆固醇酯转运蛋白、杀菌通透性增加蛋白和脂多糖结合蛋白。除了结构相似性外，脂质转运/脂多糖结合蛋白家族的成员可能具有一些共同的功能特性，最近的研究表明，磷脂转运蛋白可以参与几个不同的代谢过程。特别是，磷脂转运蛋白对磷脂、未酯化胆固醇、α-生育酚和脂多糖的分子转运表明，它可能参与脂蛋白代谢和抗菌防御，因此人们对这种蛋白的兴趣与日俱增。
