Küchle M, Nguyen N X, Martus P, Freissler K, Schalnus R
Department of Ophthalmology, University of Erlangen-Nürnberg, Germany.
Graefes Arch Clin Exp Ophthalmol. 1998 Jun;236(6):426-33. doi: 10.1007/s004170050101.
The purpose of this study was to quantify blood-ocular barrier impairment by measuring aqueous flare in retinitis pigmentosa (RP) and to search for clinical correlations.
Forty-nine patients (94 eyes) with RP and 85 normal controls were examined. Aqueous flare was quantified with the noninvasive laser flare-cell meter (FC-1000, Kowa, Japan). Degrees of cystoid macular edema (CME), vitreous pigment dusting (VPD), intraretinal migration of retinal pigment epithelium, and waxy pallor of the optic nerve head were determined semiquantitatively by biomicroscopy. Data were analyzed using the t-test the Mann-Whitney U-test, the chi-squared test and regression analysis by taking into account the dependency of data from two eyes of the same patients.
Aqueous flare (photon counts/ms) was significantly higher in RP (mean 10.11 +/- 3.53) than in normals (3.89 +/- 0.94; P < 0.001). Clinically significant CME was present in 26% of eyes with RP, being significantly more frequent in autosomal dominant RP (11 of 16 eyes, 69%) than in other variants (17%; P < 0.005). Multivariate analysis revealed that CME was most strongly associated with flare values (r = 0.84), P < 0.01), whereas--after adjusting for CME--correlations between aqueous flare and other clinical findings did not reach significance.
RP eyes show increased aqueous flare values, indicating impairment of blood-occur barriers. This appears to be associated with CME and with autosomal dominant RP.
本研究的目的是通过测量色素性视网膜炎（RP）患者的房水闪光来量化血-眼屏障损伤，并寻找临床相关性。
对49例RP患者（94只眼）和85名正常对照者进行了检查。使用非侵入性激光闪光细胞仪（FC-1000，日本兴和）对房水闪光进行量化。通过生物显微镜对黄斑囊样水肿（CME）、玻璃体色素沉着（VPD）、视网膜色素上皮细胞视网膜内迁移以及视神经乳头蜡样苍白的程度进行半定量测定。在考虑同一患者双眼数据的依赖性的情况下，使用t检验、Mann-Whitney U检验、卡方检验和回归分析对数据进行分析。
RP患者的房水闪光（光子计数/毫秒）（平均值10.11±3.53）显著高于正常对照者（3.89±0.94；P<0.001）。26%的RP患者眼中存在具有临床意义的CME，常染色体显性RP患者中出现CME的频率（16只眼中有11只，69%）显著高于其他类型（17%；P<0.005）。多变量分析显示，CME与闪光值相关性最强（r=0.84，P<0.01），而在对CME进行校正后，房水闪光与其他临床发现之间的相关性未达到显著水平。
RP患者的眼房水闪光值升高，表明血-眼屏障受损。这似乎与CME以及常染色体显性RP有关。
