Tartour E, Fridman W H
INSERM U255 et Laboratoire d'Immunologie Clinique, Institut Curie, Paris, France.
Int Rev Immunol. 1998;16(5-6):683-704. doi: 10.3109/08830189809043014.
The relationships between cytokines and cancer are multiple and bidirectional. On the one hand, cytokines may directly influence carcinogenesis and metastasis by modifying the tumor phenotype. On the other hand, during tumor progression, modifications of the cytokine expression in the tumor environment may be induced by the tumor cells, leading to a state of immunosuppression reflected by low cytokine expression in tumor stroma. Cytokines also play a role by stimulating the host immune system to generate anti-tumor specific responses. Finally, the use of cytokines as anti-tumor agents has led to objective clinical responses in about 15-25% of patients with metastatic melanoma or renal cell carcinoma, which presents the basis for the development of promising immunotherapeutic approaches for cancer therapy.
细胞因子与癌症之间的关系是多方面且双向的。一方面，细胞因子可通过改变肿瘤表型直接影响致癌作用和转移。另一方面，在肿瘤进展过程中，肿瘤细胞可能诱导肿瘤环境中细胞因子表达的改变，导致肿瘤基质中细胞因子低表达所反映的免疫抑制状态。细胞因子还通过刺激宿主免疫系统产生抗肿瘤特异性反应发挥作用。最后，将细胞因子用作抗肿瘤药物已在约15%至25%的转移性黑色素瘤或肾细胞癌患者中产生了客观的临床反应，这为开发有前景的癌症免疫治疗方法奠定了基础。
