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血清白细胞介素-8和干扰素-α在甲状腺疾病中的临床应用价值

Clinical utility of serum interleukin-8 and interferon-alpha in thyroid diseases.

作者信息

Kobawala Toral P, Patel Girish H, Gajjar Dhara R, Patel Kamini N, Thakor Premal B, Parekh Urvi B, Patel Kirti M, Shukla Shilin N, Shah Pankaj M

机构信息

Division of Molecular Endocrinology, The Gujarat Cancer and Research Institute, NCH Compound, Asarwa, Ahmedabad 380 016, India.

出版信息

J Thyroid Res. 2011 Mar 8;2011:270149. doi: 10.4061/2011/270149.

DOI:10.4061/2011/270149
PMID:21461397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3065012/
Abstract

Serum interleukin-8 (IL-8) and interferon-alpha (IFN-α) levels have been estimated from a total of 88 individuals of which 19 were disease-free healthy individuals, and 69 were patients with thyroid diseases: goitre (N = 21), autoimmune diseases (N = 16), and carcinomas (N = 32). Both IL-8 and IFN-α were significantly higher in all the patients as compared to healthy individuals. Serum IL-8 levels showed significant positive correlation with disease stage in thyroid cancer patients. Higher serum IL-8 levels were associated with advanced disease stage while no significant correlation was observed between serum IFN-α levels and any of the clinicopathological parameters. IL-8 and IFN-α significantly correlated with each other in anaplastic carcinoma patients. Finally concluding, monitoring the serum IL-8 and IFN-α levels can help differentiate patients with thyroid diseases from healthy individuals, and IL-8 seems to have a role in the pathogenesis of thyroid diseases and may represent a target for innovative diagnostic and therapeutic strategies.

摘要

已对总共88名个体的血清白细胞介素-8(IL-8)和干扰素-α(IFN-α)水平进行了评估,其中19名是无病的健康个体,69名是甲状腺疾病患者:甲状腺肿(N = 21)、自身免疫性疾病(N = 16)和癌症(N = 32)。与健康个体相比,所有患者的IL-8和IFN-α水平均显著更高。甲状腺癌患者的血清IL-8水平与疾病分期呈显著正相关。血清IL-8水平较高与疾病晚期相关,而血清IFN-α水平与任何临床病理参数之间均未观察到显著相关性。在间变性癌患者中,IL-8和IFN-α彼此显著相关。最后得出结论,监测血清IL-8和IFN-α水平有助于区分甲状腺疾病患者和健康个体,并且IL-8似乎在甲状腺疾病的发病机制中起作用,可能代表创新诊断和治疗策略的一个靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4fc/3065012/244556193812/JTR2011-270149.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4fc/3065012/4669d98daea2/JTR2011-270149.001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4fc/3065012/ef7a8e00155a/JTR2011-270149.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4fc/3065012/d80e3ea3cc18/JTR2011-270149.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4fc/3065012/244556193812/JTR2011-270149.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4fc/3065012/4669d98daea2/JTR2011-270149.001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4fc/3065012/ef7a8e00155a/JTR2011-270149.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4fc/3065012/d80e3ea3cc18/JTR2011-270149.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4fc/3065012/244556193812/JTR2011-270149.004.jpg

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