Arnold D L, Wolinsky J S, Matthews P M, Falini A
Montreal Neurological Institute, McGill University, Quebec, Canada.
J Neurol Neurosurg Psychiatry. 1998 May;64 Suppl 1:S94-101.
Magnetic resonance spectroscopic imaging (MRSI) can be used to define specific chemical-pathological changes in the brain of patients with multiple sclerosis. Magnetic resonance spectroscopy offers promise for improved definition of the nature of individual lesions, the dynamics of their evolution, their effects on normal appearing white matter, and their relation to clinical disability. Combined multimodal MRSI studies of the brains of patients with multiple sclerosis therefore soon may provide efficient, specific, and quantitative new approaches to assessment of drug effects in therapeutic trials.
磁共振波谱成像（MRSI）可用于确定多发性硬化症患者大脑中的特定化学病理变化。磁共振波谱有望更好地界定单个病灶的性质、其演变动态、对正常外观白质的影响以及与临床残疾的关系。因此，对多发性硬化症患者大脑进行联合多模态MRSI研究，可能很快会为治疗试验中药物疗效评估提供高效、特异且定量的新方法。
