通过磁共振波谱和成像技术观察与年龄相关的海马体代谢物变化和体积损失。
Age-related metabolite changes and volume loss in the hippocampus by magnetic resonance spectroscopy and imaging.
作者信息
Schuff N, Amend D L, Knowlton R, Norman D, Fein G, Weiner M W
机构信息
Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, and University of California, San Francisco, CA 94121, USA.
出版信息
Neurobiol Aging. 1999 May-Jun;20(3):279-85. doi: 10.1016/s0197-4580(99)00022-6.
Magnetic resonance imaging (MRI) studies have produced controversial results concerning the correlation of hippocampal volume loss with increasing age. The goals in this study were: 1) to test whether levels of N-acetyl aspartate (NAA, a neuron marker) change in the hippocampus during normal aging and 2) to determine the relationship between hippocampal NAA and volume changes. Proton magnetic resonance spectroscopic imaging (1H MRSI) and MRI were used to measure hippocampal metabolites and volumes in 24 healthy adults from 36 to 85 years of age. NAA/Cho decreased by 24% (r = 0.53, p = 0.01) and NAA/Cr by 26% (r = 0.61, p < 0.005) over the age range studied, whereas Cho/Cr remained stable, implying diminished NAA levels. Hippocampal volume shrank by 20% (r = 0.64, p < 0.05). In summary, aging effects must be considered in 1H MRSI brain studies. Furthermore, because NAA is considered a marker of neurons, these results provide stronger support for neuron loss in the aging hippocampus than volume measurements by MRI alone.
磁共振成像（MRI）研究在海马体体积减少与年龄增长的相关性方面得出了有争议的结果。本研究的目的是：1）测试在正常衰老过程中，海马体中N-乙酰天门冬氨酸（NAA，一种神经元标志物）的水平是否发生变化；2）确定海马体NAA与体积变化之间的关系。使用质子磁共振波谱成像（1H MRSI）和MRI来测量24名年龄在36至85岁之间的健康成年人的海马体代谢物和体积。在所研究的年龄范围内，NAA/Cho下降了24%（r = 0.53，p = 0.01），NAA/Cr下降了26%（r = 0.61，p < 0.005），而Cho/Cr保持稳定，这意味着NAA水平降低。海马体体积缩小了20%（r = 0.64，p < 0.05）。总之，在1H MRSI脑研究中必须考虑衰老效应。此外，由于NAA被认为是神经元的标志物，这些结果比仅通过MRI进行的体积测量更有力地支持了衰老海马体中的神经元损失。
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