一种与宿主保护性绵羊带绦虫和牛带绦虫18 kDa抗原同源的猪带绦虫六钩蚴蛋白。
A Taenia solium oncosphere protein homologous to host-protective Taenia ovis and Taenia saginata 18 kDa antigens.
作者信息
Gauci C G, Flisser A, Lightowlers M W
机构信息
Molecular Parasitology Laboratory, University of Melbourne, Werribee, Victoria, Australia.
出版信息
Int J Parasitol. 1998 May;28(5):757-60. doi: 10.1016/s0020-7519(98)00034-4.
A Taenia solium cDNA (TSOL-18) encoding a protein with close homology to host protective oncosphere antigens from Taenia ovis (To18) and Taenia saginata (TSA-18) is described here. TSOL-18 was cloned from mRNA obtained from hatched and activated oncospheres of T. solium. The high level of predicted amino acid sequence homology among TSOL-18 and other host protective taeniid antigens suggests that the protein expressed by TSOL-18 may be capable of being used as a vaccine against T. solium infection in the parasite's intermediate hosts.
本文描述了一种猪带绦虫cDNA（TSOL-18），其编码的蛋白质与来自绵羊带绦虫（To18）和牛带绦虫（TSA-18）的宿主保护性六钩蚴抗原具有高度同源性。TSOL-18是从猪带绦虫孵化并激活的六钩蚴中获得的mRNA克隆而来。TSOL-18与其他宿主保护性带科绦虫抗原之间预测的氨基酸序列高度同源，这表明TSOL-18表达的蛋白质可能能够用作针对该寄生虫中间宿主中猪带绦虫感染的疫苗。
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